What is a sign of Peutz-Jeghers Syndrome?

Peutz-Jeghers Syndrome is characterized by the presence of distinctive mucocutaneous pigmentation, particularly brown macules on the lips and around the oral cavity. These brown spots are typically non-malignant and can also be found on other areas such as the face, hands, and feet. The presence of these pigmented lesions is an important clinical marker for the syndrome and aids in its identification during examinations.

In the context of this syndrome, the other choices do not represent features commonly associated with Peutz-Jeghers Syndrome. White spots on the tongue, red macules on the gums, and blue discoloration of the cheeks are not characteristic findings linked to this condition, making them less relevant when diagnosing or evaluating for Peutz-Jeghers Syndrome. The distinguishing brown macules on the lips serve as a visual cue, helping to alert clinicians and patients to the potential risks of developing gastrointestinal polyps and associated malignancies linked to the syndrome.