What is the most likely side effect of prednisone?

Prednisone, a corticosteroid, is commonly associated with a variety of side effects due to its immunosuppressive and anti-inflammatory properties. Impaired wound healing is a notable side effect of prednisone. This occurs because corticosteroids can inhibit fibroblast activity and decrease collagen synthesis, which are crucial for the wound healing process. They also suppress inflammatory responses that are necessary for the initial healing stages.

This side effect is particularly significant in patients who may be undergoing surgical procedures or dealing with chronic wounds, as the medication can prolong healing times and increase the risk of infection at the wound site.

The other options, while they may be seen in some contexts, are not the primary concern associated with prednisone therapy in the same way. For instance, while gingival enlargement may occur with some medications, it is not a well-documented side effect of prednisone. Xerostomia, or dry mouth, can arise from a variety of factors and is not specifically linked to prednisone. Delaying blood pressure changes are not a primary side effect of corticosteroids, although they can cause hypertension in some patients. Overall, the impact on wound healing stands out as a critical consideration for those prescribed prednisone.