What side effect is often associated with prolonged use of corticosteroids?

Prolonged use of corticosteroids is commonly associated with delayed wound healing due to their impact on various aspects of the immune system and tissue repair processes. Corticosteroids suppress inflammation, which is a crucial aspect of the body’s healing response. They also impair the function of immune cells and can affect the synthesis of proteins needed for tissue repair, ultimately leading to longer recovery times for wounds. This effect can significantly hinder the body's ability to heal properly after injury or surgery, making delayed wound healing a prominent side effect of extended corticosteroid therapy.

Other side effects such as increased salivation, gastric ulcers, and hyperactive reflexes are not typically attributed to long-term corticosteroid use. While corticosteroids can lead to gastric ulcers due to their effect on the gastric mucosa, the primary and more immediate concern with prolonged use remains the delay in wound healing.