What symptom is most frequently associated with the use of anti-hypertensive calcium channel blockers?

The most frequently associated symptom with the use of anti-hypertensive calcium channel blockers is painless swelling of gum tissues, known as gingival hyperplasia. This side effect occurs because calcium channel blockers can cause fibrous tissue proliferation in the gums, particularly with long-term use. The presence of these medications can lead to an increase in the collagen synthesis by fibroblasts in the gum tissue, resulting in swelling and sometimes a change in the appearance of the gums without pain.

In contrast, dry mouth is typically associated with medications that have anticholinergic effects, which are not characteristic of calcium channel blockers. Frequent urination may occur with diuretics, but this is not a common side effect of calcium channel blockers. Weight loss is not a direct side effect related to calcium channel blocker medications either, as these are primarily used to manage blood pressure rather than to impact weight. Thus, painless swelling of gum tissues is the notable symptom tied to the use of calcium channel blockers among the options provided.