When biopsying a mixed lesion, which area should be sampled?

Sampling both the red and white portions of a mixed lesion is crucial because different areas may represent different pathological processes. Mixed lesions often have distinct characteristics that can suggest various diagnoses. The red portion may indicate inflammation or vascular changes, while the white portion could represent fibrotic tissue or dysplastic changes.

By obtaining a biopsy from both areas, there is a greater chance of capturing a comprehensive picture of the lesion. This approach allows for a more accurate interpretation of the underlying conditions present and facilitates a proper diagnosis, which is essential for determining the appropriate treatment plan. Analyzing only one part may result in missing critical information that could guide clinical decisions.