Which condition is associated with an increased risk of thrombosis?

The association between a history of infective endocarditis and an increased risk of thrombosis stems from the pathological processes that occur during and after the infection. Infective endocarditis is characterized by the presence of vegetations on the heart valves, which are composed of platelets, fibrin, and microorganisms. This condition can lead to damage of the endocardial surface and disrupt the normal blood flow patterns, which promotes clot formation, or thrombosis.

Moreover, the inflammation and immune response triggered by the infection can create a hypercoagulable state, further enhancing the risk of blood clots forming both locally at the infection site and systemically. This increased risk is particularly relevant in patients who have undergone surgical interventions or those who may have pre-existing cardiac conditions that compound the risk of thromboembolic events.

On the other hand, a history of hypertension does not directly correlate with thrombus formation and primarily influences cardiovascular disease risk in other ways. Low cholesterol levels are generally associated with a lower risk of cardiovascular events, including thrombosis. Regular exercise is known for its cardiovascular benefits, including the reduction of thrombotic risk, by improving endothelial function and promoting healthy circulation. Therefore, the correct association lies with the history of infective endocarditis