Which condition is most likely to affect a patient's ability to wear complete dentures?

Sjogren's Syndrome is a condition that significantly affects a patient's ability to wear complete dentures primarily due to the resultant dry mouth (xerostomia) and associated oral health complications. This autoimmune disorder leads to the dysfunction of salivary and lacrimal glands, resulting in reduced saliva production. Saliva plays a crucial role in securing and stabilizing dentures; without adequate moisture, the fit can become uncomfortable, leading to sore spots and difficulty in achieving a proper seal.

Given the implications of xerostomia, patients with Sjogren's Syndrome may experience challenges such as difficulty in mastication, an increase in dental caries, and an elevated risk of oral infections, all of which can further complicate denture wearability. These factors underscore the importance of considering underlying systemic conditions when managing denture use in patients.