Which deficiency is commonly associated with the initial onset of angular cheilitis?

Angular cheilitis, characterized by inflammation and cracks at the corners of the mouth, is commonly associated with a deficiency in vitamin B2, also known as riboflavin. Riboflavin plays a crucial role in maintaining healthy mucous membranes and skin. Its deficiency can lead to a variety of oral health issues, including angular cheilitis, due to the impaired healing of mucosal tissues and decreased overall skin integrity.

In addition, riboflavin is important for energy production and acts as a precursor to coenzymes involved in the metabolism of fats, drugs, and steroids. When levels are insufficient, the body’s ability to repair and regenerate tissues is compromised, leading to the cracking and inflammation seen in angular cheilitis.

While other vitamin deficiencies can contribute to oral health issues, they are not as closely linked to the development of angular cheilitis as riboflavin deficiency. For instance, vitamin B12 deficiency is more commonly associated with pernicious anemia and glossitis rather than angular cheilitis.