Which syndrome is characterized by micrognathia, cleft palate, and glossoptosis?

The correct choice is indeed Pierre Robin Syndrome, which is specifically known for its triad of features: micrognathia (a condition where the jaw is unusually small), cleft palate, and glossoptosis (the posterior positioning of the tongue). These characteristics are related to the developmental issues that occur during embryogenesis, affecting the formation of the jaw and associated structures.

In Pierre Robin Syndrome, the small jaw can lead to problems with breathing and feeding, largely due to the way the tongue is positioned. The cleft palate can further complicate these issues. This syndrome is important to recognize for its implications in the management of a patient’s airway and feeding strategies.

In contrast, Down syndrome is a chromosomal condition characterized by cognitive impairment and unique physical features, but not specifically by the triad seen in Pierre Robin Syndrome. Treacher Collins syndrome involves craniofacial abnormalities including underdeveloped facial bones, but does not typically feature a cleft palate or glossoptosis as defining characteristics. Marfan syndrome primarily affects connective tissue and has features such as long limbs and cardiovascular complications, rather than the specific oral-facial abnormalities seen in Pierre Robin Syndrome.