Which treatment is best suited for oral lesions such as major aphthous ulcers?

The use of systemic steroids for the treatment of major aphthous ulcers is based on their ability to effectively reduce inflammation and promote healing. Major aphthous ulcers are painful and can significantly interfere with oral function and quality of life. Systemic steroids, such as prednisone, have potent anti-inflammatory properties that can help to minimize the severity and duration of these ulcers, making them particularly useful in cases where topical treatments may not be sufficient.

While topical analgesics and anesthetics might provide temporary relief from pain, they do not address the underlying inflammation or expedite healing of the ulcer itself. Oral antibiotics are not indicated in this scenario, as major aphthous ulcers are not caused by bacterial infections. Thus, systemic steroids are the most appropriate choice in managing major aphthous ulcers due to their effectiveness in controlling the inflammatory response and promoting healing.